Cases of black widow (Latrodectus indistinctus) and brown widow (L. ge
ometricus) spider bites referred to the Tygerberg Pharmacology and Tox
icology Consultation Centre from the summer of 1987/88 to the summer o
f 1991/92 were entered into this series. Of a total of 45 patients, 30
had been bitten by black and 15 by brown widow spiders. It was eviden
t that black widow spider bites caused a more severe form of envenomat
ion than brown widow bites, characterised by generalised muscle pain a
nd cramps, abdominal muscle rigidity, profuse sweating, raised blood p
ressure and tachycardia. The symptoms and signs of brown widow bites w
ere mild and tended to be restricted to the bite site and surrounding
tissues. Conditions which should be considered in the differential dia
gnosis include cytotoxic spider bite, scorpion sting, snakebite, acute
abdominal conditions, myocardial infarction, alcohol withdrawal and o
rganophospate poisoning. To prevent the development of complications,
the administration of black widow spider antivenom is recommended in s
evere cases because untreated latrodectism could become protracted, wi
thout improvement, for several days.