Mb. Neuss et al., OCCLUSION OF THE NEONATAL PATENT DUCTUS-ARTERIOSUS WITH A SIMPLE RETRIEVABLE DEVICE - A FEASIBILITY STUDY, Cardiovascular and interventional radiology, 19(3), 1996, pp. 170-175
Purpose: To examine the feasibility of transvenous placement of a new
memory-shaped, small, retrievable coil that has a smaller-caliber deli
very system than currently available devices, for closure of the paten
t ductus arteriosus (PDA). Methods: Through 4 or 5 Fr vascular sheaths
and 4 or 5 Fr end-hold catheters, the coils were delivered and placed
in piglets (n = 10) with PDA. The coils were made from 0.018'' (0.46
mm) or 0.028'' (0.71 mm) stainless steel guidewire. Mounted for delive
ry, the new device has the appearance of a conventional guidewire. Thi
s neonatal PDA model was created without major surgery or drugs by ste
nting the ductus arteriosus. Results: The memory-shaped coils were eas
ily delivered. Coils not optimally placed were retrieved and repositio
ned. Occlusion of the ductus arteriosus as early as a half-hour after
delivery was shown angiographically and confirmed by histopathology. C
onclusion: This new, small-caliber, simple device was found to be effe
ctive for closure of the PDA in this animal model. Longer-term observa
tions are needed.