Cognitive decline is a common feature of ageing, sometimes gentle at o
ther times less so. It manifests as a wide spectrum from cognitive imp
airment that is not dementia to Alzheimer's disease and to the much ra
rer but potentially enlightening familial forms. The Lancet's 1996 int
ernational conference was held in Edinburgh, UH, on April 25 and 26. T
he meeting brought together epidemiologists, geneticists, neuropsychol
ogists, neuropathologists, clinicians, and imaging specialists, and th
ose concentrating on the social and ethical aspects of the dementias.
Half the conference was devoted to discussion that crossed specialty b
oundaries. This report highlights the major areas of agreement and con
troversy and points to opportunities for future multidisciplinary rese
arch.