DEVELOPMENT OF AN OPTIMAL SCHEME OF INTER PRETING THE RESULTS OF USING ENZYME-IMMUNOASSAY SYSTEM FOR THE ASSESSMENT OF THE ANTIGENIC ACTIVITY OF CULTURAL ANTIRABIES VACCINE

Ninety-eight lots of commercial antirabies vaccine manufactured by Imm unopreparat Research and Production Amalgamation have been tested usin g enzyme immunoassay system for the detection of rabies virus antigens . Comparison of different variants of interpreting and expressing the results helped define the optimal method for assessment of vaccine tit er and reference values: optical density value equal to 0.2 is taken a s the cut-off. Antigenic activity of the vaccine may be expressed in i nternational units, similarly as immunogenic activity.