OVARIAN EFFECTS UPON MATERNAL GLUCOSE-TOLERANCE

Ovaries from homozygous diabetic (db/db) female mice were removed and transplanted into the empty left ovarian sacs of normal homozygous (m/ m) female mice which had undergone left oophorectomies. To produce con trols, the previously removed normal left ovaries were transplanted in to the empty left ovarian sacs of other normal (m/m) left oophorectomi zed females. Glucose tolerance tests were done on the study and contro l mice before surgery, after surgery, during pregnancy, and after deli very. There were no significant differences in the glucose tolerance t est results between study group and controls before or after surgery. However, the study group, when compared to the controls, had a statist ically significant glucose intolerance during pregnancy. After deliver y, the glucose levels returned to normal. The ovaries from diabetic (d b/db) female mice may produce hormones which, by themselves or in conc ert with the fetal and placental hormones, may produce maternal glucos e intolerance during pregnancy.