Gabapentin (GBP) is a new antiepileptic drug (AED) approved for adjunc
tive treatment of complex partial seizures with or without seizures se
condarily generalization in adults. We report 2 children who received
GBP for intractable seizures and who developed intolerable aggressive
behavior requiring dose reduction or drug discontinuation. Behavioral
changes should be recognized as a possible side effect of GBP, especia
lly in mentally retarded children.