THE APPLICATION OF VINYLOGOUS IMINIUM SALTS AND RELATED SYNTHONS TO THE REGIOCONTROLLED PREPARATION OF 2,3-DISUBSTITUTED AND 2,5-DISUBSTITUTED PYRROLES
Jt. Gupton et al., THE APPLICATION OF VINYLOGOUS IMINIUM SALTS AND RELATED SYNTHONS TO THE REGIOCONTROLLED PREPARATION OF 2,3-DISUBSTITUTED AND 2,5-DISUBSTITUTED PYRROLES, Tetrahedron, 52(20), 1996, pp. 6879-6892
The reaction of 1-substituted vinamidinium salts with sarcosine ethyl
ester produced 2,3-disubstituted pyrroles; a similar reaction with gly
cine ethyl ester gave 2,5-disubstituted pyrroles. Reactions of related
three-carbon synthons with sarcosine and glycine were studied under b
asic, neutral and acidic conditions which demonstrated the utility of
these derivatives for the regiocontrolled preparation of disubstituted
pyrroles. Copyright (C) 1996 Elsevier Science Ltd