NEW NITROGENOUS AND AROMATIC DERIVATIVES FROM AGLAIA-ARGENTEA AND AGLAIA-FORBESII

Seeds and leaves of Aglaia orgentea and bark of A. forbesii were extra cted, The known cyclopentatetrahydrobenzofuran derivative rocaglaol (1 ) and the aminopyrrolidine odorine (5), were isolated together with ni ne new compounds : didesmethylrocaglamide (6), aglains A (7), 8 (8) an d C (9), aglaforbesins A (10) and B (11), ethylrocaglaol (12) and forb aglins A (13) and B (14). Compounds 7-11 and 13,14 possess a new cyclo pentatetrahydrobenzopyran and benzoxepine skeleton, respectively, link ed to an odorine type moiety. All the structures were elucidated notab ly by 2D NMR spectroscopy. In addition, the structure of forbaglin A w as established by X-Ray crystallographic analysis. Didesmethylrocaglam ide revealed strong cytotoxic activity against KB cells (IC50 0.006 mu g/ml). Copyright (C) 1996 Elsevier Science Ltd