Uc. Nzeako et al., HEPATOCELLULAR-CARCINOMA AND NODULAR REGENERATIVE HYPERPLASIA - POSSIBLE PATHOGENETIC RELATIONSHIP, The American journal of gastroenterology, 91(5), 1996, pp. 879-884
Objective: In a recent review of hepatocellular carcinoma (HCC) in Nor
th American residents, we were surprised to learn that 42.6% of these
tumors in the 1980-1993 consultation files of the Armed Forces Institu
te of Pathology had arisen in noncirrhotic livers. We subsequently not
ed that the nonneoplastic livers of a number of these had nodular rege
nerative hyperplasia (NRH), a condition that has been associated with
liver cell dysplasia, a putative premalignant lesion. To investigate t
he possibility that NRH might be a precursor of HCC, we studied those
cases in which there was an association of HCC and NRH and examined th
e possible role of portal vein obstruction in NRH occurring in livers
with HCC. Methods: Subjects were selected based on study criteria and
histological slides, clinical/autopsy records were reviewed, and featu
res of neoplastic and nonneoplastic liver were noted. Simple statistic
al comparisons were made between the groups with and without NRH with
respect to defined variables. Results: Of 804 patients suitable for st
udy, 342 were noncirrhotic, and 23 of these had NRH. Mean age of patie
nts with NRH was 65 +/- 13.6 (SD) yr. Seventeen of these (73.9%) had l
iver cell dysplasia, and 16 (69.6%) had portal venous invasion. Liver
cell dysplasia occurred in a significantly greater proportion of those
with NRH than those without (p < 0.01), but there was no significant
difference between both groups with regard to portal venous invasion.
Three patients (13%) had received chemotherapy and/or radiotherapy bef
ore diagnosis of NRH. Conclusions: These findings may be due to the de
velopment of HCC within the dysplastic foci that occur in livers with
NRH, but the findings do not exclude the converse possibility that NRH
may also develop in a noncirrhotic liver with HCC, secondary to porta
l venous invasion with portal vein occlusion. The temporal relationshi
p between HCC and NRH is probably determined in each case by the parti
cular interaction of multiple pathogenetic factors. Among patients wit
h HCC, factors other than portal vein obstruction by tumor invasion ma
y play a role in the pathogenesis of NRH.