PERIANAL CROHNS-DISEASE IN CHILDREN AND ADOLESCENTS

Objectives: To review the frequency, severity, course, and outcome of perianal Crohn's disease in children and adolescents. Methods: Records of 141 children and adolescents with Crohn's disease were reviewed. O f these, 18 patients (eight female, 10 male) between 9 and 18 yr of ag e (nine blacks and nine whites) had significant perianal disease. The disease was classified on the basis of external appearance, degree of inflammation, presence of infection or abscess formation, spread to vu lva, loss of perineal body, and occurrence of anal canal stricture as being mild, moderate, or severe. Results: Eight patients had severe in volvement, whereas moderate and mild degree of perianal disease was se en in six and four patients, respectively. Disease localization was as follows: pancolitis, 12; ileocolitis, four; and left colitis, two. Th erapy with Azulfidine or 5-amino salicylic acid preparation, local and systemic steroids, metronidazole, immunosuppressives, and enteral and /or parenteral nutrition was used in various combinations. Surgery was necessary in eight patients: in four for management of anal canal str icture. incision and drainage of abscess in two, total proctocolectomy in one, and fecal diversion in an additional patient. Over a follow-u p period ranging from 18 months to 15 yr, nine patients had partial im provement, whereas in the rest, the disease either did not improve or worsened. Conclusions: Severe, mutilating perianal Crohn's disease, ca using significant tissue destruction, occurs in both sexes and is extr emely refractory to treatment in the majority of patients. The outcome in mild and moderate disease is better.