In this report, we describe the case of a 28-yr-old woman with sickle
cell anemia who presented with acute hepatic failure manifested by ano
rexia, malaise, painless jaundice, elevated aminotransferase activitie
s, and severe coagulopathy, Liver biopsy revealed changes consistent w
ith autoimmune hepatitis, Treatment with corticosteroids and azathiopr
ine was followed by improvement in biochemical liver test results, The
literature on sickle cell-associated liver diseases is reviewed.