STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF XANTHONE AND FLUORENONE-1,4-DIHYDROPYRIDINE-5-PHOSPHONATES

Authors
BUDRIESI R RAMPA A BISI A FABBRI G CHIARINI A VALENTI P
Citation
R. Budriesi et al., STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF XANTHONE AND FLUORENONE-1,4-DIHYDROPYRIDINE-5-PHOSPHONATES, Arzneimittel-Forschung, 46(4), 1996, pp. 374-377
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
46
Issue
4
Year of publication
1996
Pages
374 - 377
Database
ISI
SICI code
0004-4172(1996)46:4<374:SRSOXA>2.0.ZU;2-A
Abstract
A series of xanthone and fluorenone-1,4-dihydropyridine derivatives be aring a 5-phosphonate group were prepared. The compounds were evaluate d for inotropic, chronotropic and calcium antagonistic properties. The insertion of a phosphonate group is detrimental for inotropic and cal cium antagonistic activity but improves the potency and selectivity fo r chronotropism.