REDUCED NEUTRAL DNASE ACTIVITY IN THE URINE OF CHILDREN AFTER CYTOSTATIC THERAPY

In children with cancer a reduced neutral urine DNase activity was obs erved at the end of cytostatic therapy. It is presumed that disorders in the kidney functions are the cause. A low neutral DNase activity is found in the blood; the activity is inhibited by inhibitors. The inhi bitors of the enzyme are split away in the kidneys so that the neutral DNase activity in urine increases. Many cytostatic drugs can induce d amage to the kidneys. This may be the reason that not all inhibitors o f neutral DNase are split away in the kidneys and the activity of the neutral urine DNase is reduced at the end of cytostatic therapy. The p rocess of removing the inhibitors is independent of the filtering capa city of the kidneys.