1-(2-TETRAHYDROFURYL)-5-FLUOROURACIL IN COMBINATION WITH URACIL SUPPRESSES MAMMARY CARCINOGENESIS AND GROWTH OF TUMORS INDUCED WITH 7,12-DIMETHYLBENZ[A]ANTHRACENE IN RATS

Authors
SAKAMOTO S KUDO H SUZUKI S SASSA S YOSHIMURA S NAKAYAMA T MAEMURA M MITAMURA T
Citation
S. Sakamoto et al., 1-(2-TETRAHYDROFURYL)-5-FLUOROURACIL IN COMBINATION WITH URACIL SUPPRESSES MAMMARY CARCINOGENESIS AND GROWTH OF TUMORS INDUCED WITH 7,12-DIMETHYLBENZ[A]ANTHRACENE IN RATS, Anti-cancer drugs, 7(2), 1996, pp. 199-203
Citations number
14
Categorie Soggetti
Oncology,"Pharmacology & Pharmacy
Journal title
Anti-cancer drugs → ACNP
ISSN journal
09594973
Volume
7
Issue
2
Year of publication
1996
Pages
199 - 203
Database
ISI
SICI code
0959-4973(1996)7:2<199:1ICWUS>2.0.ZU;2-Q
Abstract
The effects of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination wit h uracil (UFT) on mammary carcinogenesis and growth of tumors induced with 7,12-dimethylbenz[a]anthracene (DMBA) were investigated in rats. Daily oral administration of UFT reduced the incidence and number of m ammary tumors compared with those of the DMBA control group, resulting in lower activities in DNA synthesizing enzymes, thymidylate syntheta se and thymidine kinase, and a reduction of bromodeoxyuridine-immunore active (S-phase) cells in mammary tumors of UFT-treated rats.