THE EFFECTS OF L-DEPRENYL ON SPATIAL, SHORT-TERM-MEMORY IN YOUNG AND AGED DOGS

1. Young and aged dogs were tested on a spatial memory task using a de layed non matching to sample technique. Dogs were tested with 20, 70 a nd 110 second delay intervals. Animals were pretrained to a stable lev el of performance prior to treatment. 2. During treatment periods, dog s were orally administered a placebo or L-deprenyl in doses of 0.5 and 1.0 mg/kg in a repeated measures design. 3. Young dogs did not show a ny significant effects of L-deprenyl, however the sample size was limi ted. 4. L-deprenyl administration improved spatial memory in aged dogs 5. The optimal dose or length of treatment time of L-deprenyl varied among individual dogs.