TOPICAL TRETINOIN (RETINOIC ACID) IMPROVES EARLY STRETCH MARKS

Background and Design: Stretch marks are disfiguring lesions usually c aused by excessive stretching of skin. We investigated the response of early, clinically active stretch marks to topical 0.1% tretinoin (ret inoic acid) cream. In a double-blind, randomized, vehicle-controlled s tudy, 22 patients applied either 0.1% tretinoin (n=10) or vehicle (n=1 2) daily for 6 months to the affected areas. Patients were evaluated b y physical examination monthly and by analysis of biopsy specimens of stretch marks obtained before and at the end of therapy in comparison with untreated normal skin. Results: After 2 months, patients treated with tretinoin had significant improvement in severity scores of stret ch marks compared with patients who received vehicle (P<.05). After 6 months, eight (80%) of the 10 tretinoin-treated patients had definite or marked improvement compared with one (8%) of the 12 vehicle-treated patients (P=.002). Targeted stretch marks in patients treated with tr etinoin had a decrease in mean length and width of 14% and 8%, respect ively, compared with an increase of 10% (P<.001) and 24% (P=.008), res pectively, in patients who received vehicle. There were no significant differences in various measures of quality and quantity of dermal col lagen and elastic fibers in stretch marks when tretinoin and vehicle t reatments were compared. Conclusions: Topical application of tretinoin significantly improves the clinical appearance of early, active stret ch marks. The processes that are responsible for the clinical improvem ent remain unknown.