THERAPY OF LYME-BORRELIOSIS IN CHILDREN

A retrospective open study was conducted to determine the efficacy of penicillin and ceftriaxone in children with skin manifestations of Lym e borreliosis (solitary erythema migrans, multiple erythemata, borreli al lymphocytoma) and neuroborreliosis, respectively, One hundred sixty children were treated with penicillin and 41 with ceftriaxone for an average of 12 days. Serum antibodies to borreliae were determined befo re therapy and 23 and 4-6 weeks thereafter. At admission 44%/26%, 8%/4 2%, and 40%/35% of erythema migrans, borrelial lymphocytoma and neurob orreliosis patients, respectively, were IgM/IgG positive. Four to 6 we eks after treatment the percentage of seropositives was 20%/15%, 8%/61 %, and 21%/44%, respectively. A 3 months follow-up was completed with 151 children, No child showed clinical evidence of illness, nor were t here abnormalities in laboratory parameters.