To assess physician preferences in the diagnosis and treatment of Lyme
disease, questionnaires were sent to physicians in various Lyme disea
se endemic areas in the U. S. Seventy-eight responses were analyzed, B
oth ELISA and Western blot were ordered by 86% of responders. Fifty pe
rcent of responders believed that 25% or more of patients who have Lym
e disease were seronegative. The treatment was influenced by physician
specialty. Antibiotic treatment for tick bite was prescribed by 20% o
f responders, Erythema migrans rash was treated by all responders with
out serologic confirmation. The median treatment duration of erythema
migrans was 4 weeks. For post-erythema migrans Lyme disease, 43% of re
sponders treat 3 months or more; for chronic Lyme disease, 57% of resp
onders treat 3 months or more, Our survey documents significant differ
ences between published recommendations and actual practices. Physicia
n education and clinical trials are needed to clarify the reasons for
these differences.