DOSE-DEPENDENT EFFECTS OF THE COMBINATION OF ANTIOXIDANTS OF VARIOUS CLASSES, DIBUNOL AND BETA-CAROTENE, TAKEN AS EXAMPLES

En order to enhance antioxidant protection of the organism in various pathological states, effective combinations of antioxidants have been developed that interact with various types of free radicals. On two ex perimental models, -acute alcohol intoxication and calcium chloride ar rhythmia of rats, the prophylactic activity of antioxidant combination s was established for certain doses, rather then for monotherapy. The possibility of obtaining high protective effects at relatively low con centrations of the components in the complex preparation was shown. Am increase of antioxidant concentration in the preparation could decrea se its efficiency. The highest efficiency in the complex preparations, as compared with in each component taken separately, was observed in the case of calcium chloride arrhythmia when dibunol and beta-carotene were combined at concentrations of 10 mg/kg and in the case of acute alcohol intoxication (1 and 0.25 mg/kg, respectively). Enhanced effici ency of combined antioxidant therapy opens up the way to the productio n of new active complex preparations with minimum toxic side toxic eff ects and complications.