CYTOGENETIC EFFECT OF VOLATILE COMPONENTS OF URINE OF MATURE ANIMALS ON BONE-MARROW CELLS OF YOUNG FEMALE HOUSE MICE MUS-MUSCULUS L

Effects of volatile components of the urine (VCU) of mature male and f emale CBA/LacStoRap mice on proliferating bone marrow cells in young f emales of the same line were analyzed. To estimate the effects of VCU, cytogenetic analysis of mitotic disturbances in anaphase-telophase ce lls was performed. The overall frequency of mitotic disturbances such as chromosome bridges, fragments, retarded chromosomes, and multiple r earrangements was assessed. The overall frequency of mitotic disturban ces in young female mice treated with VCU from mature females for 2 h significantly increased 24 h after exposure. The spectrum of mitotic d isturbances was also affected by the VCU treatment. After exposure to VCU from mature males, no significant variation of parameters analyzed was detected in young female mice. The possible mechanisms and role o f specific effects of VCU from animals of different sexes on young fem ale house mice are discussed.