ENZYME AND DNA POLYMORPHISMS OF HUMAN PLA CENTAL ALKALINE-PHOSPHATASEIN THE MORDVINIAN POPULATION

Data on DNA and enzyme polymorphisms of human placental alkaline phosp hatase (FLAP) in Mordvinian populations are presented. Restriction fra gment length polymorphism (RFLP) was detected after the digestion of D NA samples with Rsa I and Pst I endonucleases. The frequencies of the second (2) allele for FLAP Pst I and Rsa I were 0.53 and 0.199, respec tively. Comparative data suggest that there are no population differen ces between Mordvinians and Scandinavian ethnic groups. In Mordvinians gene frequencies measured at the level of gene products were PLAP1(S ) = 0.681, PLAP2(F) = 0.244, PLAP*3(I) = 0.069, and PLAP*18(D) = 0.00 6, indicating the similarity of the corresponding values in Scandinavi ans. The observed RFLP and ''protein'' genotype frequencies were in go od agreement with that expected according to the Hardy-Weinberg equati on. In the Mordvinian population, as in those, surveyed previously, a strong linkage disequilibrium between Pst I and Rsa I FLAP alleles was observed.