Ca. Gross et al., A STRUCTURE-FUNCTION ANALYSIS OF ESCHERICHIA-COLI RNA-POLYMERASE, Philosophical transactions-Royal Society of London. Biological sciences, 351(1339), 1996, pp. 475-482
Control of RNA polymerase is a common means of regulating gene express
ion. A detailed picture of both the structure and how the structural d
etails of RNA polymerase encode function is a key to understanding the
molecular strategies used to regulate RNA polymerase. We review here
data which ascribes functons to some regions of the primary sequence o
f the subunits (alpha,beta beta'sigma) which make up E. coli RNA polym
erase. We review both genetic and biochemical data which place regions
of the primary sequence that are distant from one another in close pr
oximity in the tertiary structure. Finally we discuss the implications
of these findings on the quaternary structure of RNA polymerase.