CARBOXYATRACTYLATE-SENSITIVE AND CYCLOSPORINE A-SENSITIVE UNCOUPLING IN LIVER-MITOCHONDRIA OF GROUND-SQUIRRELS DURING HIBERNATION AND AROUSAL

Authors
AMERKHANOV ZG YEGOROVA MV MARKOVA OV MOKHOVA EN
Citation
Zg. Amerkhanov et al., CARBOXYATRACTYLATE-SENSITIVE AND CYCLOSPORINE A-SENSITIVE UNCOUPLING IN LIVER-MITOCHONDRIA OF GROUND-SQUIRRELS DURING HIBERNATION AND AROUSAL, Biochemistry and molecular biology international, 38(5), 1996, pp. 863-870
Citations number
16
Categorie Soggetti
Biology
Journal title
Biochemistry and molecular biology international → ACNP
ISSN journal
10399712
Volume
38
Issue
5
Year of publication
1996
Pages
863 - 870
Database
ISI
SICI code
1039-9712(1996)38:5<863:CACAUI>2.0.ZU;2-H
Abstract
Oxygen consumption and transmembrane electrical potential difference i n liver mitochondria from hibernating, arousing and active ground squi rrels have been compared. It is found that arousal from hibernation is accompanied by uncoupling which is mediated by two different mechanis ms, one sensitive to cyclosporin A and the other suppressed by carboxy atractylate. Both uncoupling effects reach their maxima at 20 - 25 deg rees C body temperatures. Involvement of an increase in the free fatty acid concentration in the arousal-induced uncoupling mechanisms-is di scussed.