FUNCTIONAL MAGNETIC-RESONANCE-IMAGING SHOWS LOCALIZED BRAIN ACTIVATION DURING SERIAL TRANSCRANIAL STIMULATION IN MAN

AREA and depth penetration of transcranial stimulation methods such as transcranial electrical stimulation (TES) are poorly defined. We inve stigated the feasibility of a simultaneous TES and fMRI measurement. T he aim was to compare the signal intensity changes measured using BOLD fMRI during sequential finger movement with the signal response durin g artificial transcranial stimulation. TES induced contralateral finge r contractions and in T2 weighted images a transient signal increase was observed in the area underlying the electrodes. Compared with the signal obtained during sequential finger movements, the area activated by TES was more localized, signal amplitude was smaller and there was no poststimulus undershoot. These data indicate that TES induces a lo cal blood flow increase associated with a drop in the concentration of deoxyhaemoglobin.