A ROLE FOR CENTRAL GLUCAGON-LIKE PEPTIDE-1 IN TEMPERATURE REGULATION

WE have already established that central glucagon-like peptide-1 (GLP- 1) has a role in the central control of food intake. In this study, ex periments were conducted to establish the effect of acute intraperiton eal (i.p.) and intracerebroventricular (i.c.v.) administration of GLP- 1 on temperature. Injection of 10 mu g GLP-1 i.c.v. caused a significa nt reduction in temperature over the subsequent and reduced food intak e as expected. Both effects were blocked by prior i.c.v. administratio n of the GLP-1 antagonist exendin 9-39 at a ratio of 30:1, Administrat ion of 300 mu g GLP-1 i.p. also reduced temperature over the 2 h follo wing injection but had no effect on food intake. Administration of exe ndin 9-39 alone by the i.c.v. route had no effect on temperature. Thes e results indicate that GLP-1 is a neuropeptide involved in the regula tion of temperature. Furthermore, the mechanisms that mediate the effe ct on temperature may be different from those regulating food intake g iven the effect on temperature but not food intake of i.p. GLP-1.