BILATERAL MUCOSA-ASSOCIATED LYMPHOID-TISSUE LYMPHOMAS OF PAROTID-GLANDS - A 13-YEAR INTERVAL

Benign lymphoepithelial lesions of salivary gland may have a populatio n of monoclonal B cells, There is controversy regarding the clinical s ignificance of monoclonality in these lesions. Morphologically and cli nically, benign lymphoepithelial lesions of the salivary gland with mo noclonal B cells falls within the spectrum of low-grade B-cell lymphom as of mucosa-associated lymphoid tissue, We report a case of bilateral parotid lymphomas of mucosa-associated lymphoid tissue, separated dia gnostically by a 13-year interval, Polymerase chain reaction analysis detected similar clones fn the bilateral parotid glands. This finding supports the natural history of mucosa-associated lymphoid tissue lymp homas, in addition, because mucosa-associated lymphoid tissue lymphoma s have an unpredictable period of localized disease, recognition of mo noclonality in benign lymphoepithelial lesions of salivary glands is i mportant for local cure and can be aided by combining histologic with immunohistochemical, now cytometric immunophenotyping, and Southern bl ot and/or polymerase chain reaction analysis.