THE CATALYTIC MECHANISM OF CYTOCHROME-P450 BM3 INVOLVES A 6-ANGSTROM MOVEMENT OF THE BOUND SUBSTRATE ON REDUCTION

Authors
MODI S SUTCLIFFE MJ PRIMROSE WU LIAN LY ROBERTS GCK
Citation
S. Modi et al., THE CATALYTIC MECHANISM OF CYTOCHROME-P450 BM3 INVOLVES A 6-ANGSTROM MOVEMENT OF THE BOUND SUBSTRATE ON REDUCTION, Nature structural biology, 3(5), 1996, pp. 414-417
Citations number
26
Categorie Soggetti
Biology,"Cell Biology
Journal title
Nature structural biology → ACNP
ISSN journal
10728368
Volume
3
Issue
5
Year of publication
1996
Pages
414 - 417
Database
ISI
SICI code
1072-8368(1996)3:5<414:TCMOCB>2.0.ZU;2-M
Abstract
Paramagnetic relaxation measurements show that reduction of the cytoch rome P450 BM3-substrate complex is accompanied by a structural change leading to a 6 Angstrom, movement of the substrate into the correct po sition and orientation for hydroxylation.