We present applications for a collocation method for modeling distilla
tion columns that we developed in a companion paper. We discuss implem
entation of the model, including discussion of the ASCEND system, whic
h enables us to create complex models with simple building blocks and
interactively learn to solve them. We first investigate applying the m
odel to compute minimum reflux for a given separation task, exactly so
lving nonsharp and approximately solving sharp split minimum reflux pr
oblems. We next illustrate the use of the collocation model to optimiz
e the design a single column capable of carrying out a prescribed set
of separation tasks. The optimization picks the best column diameter a
nd total number of trays. It also picks the feed tray for each of the
prescribed separations.