HEMATOLOGICAL AND BIOCHEMICAL-CHANGES IN ACUTE LEUKEMIC PATIENTS AFTER CHEMOTHERAPY

io study hematological and biochemical profiles in acute leukemic pati ents before and after chemotherapy. METHODS: Sera from 20 normal perso ns were compared with those from 40 patients of whom 20 patients were followed up after 6-8 months of treatment with cyclophosphamide, vincr istine, and prednisolone. RESULTS: Hemoglobin, hematocrit and platelet count were decreased while reticulocyte count, sedimmentation, total leukocyte count, time, bilirubin, blood coagulation time, aminotransfe rase, lactate dehydrogenase, creatinine, and urea were increased in ac ute myelocytic patients compared to normal. A similar pattern was obse rved in acute lymphocytic patients except there was no significant inc rease in serum urea. CONCLUSION: In acute leukemic patients blood chem istry and hematology are useful during diagnosis and treatment. After 6 - 8 months of treatment 50 % remission occurred.