EFFECT OF PHENCYCLIDINE ON DOG CORONARY-ARTERY

AIM: To study the effect of phencyclidine (Phe) on dog coronary artery . METHODS: Contraction of spiral strips of dog coronary artery in bioa ssay and coronary artery blood flow (CBF) using electromagnetic flowme ter on anesthetized dogs were observed. RESULTS: Phe 0.1-100 mu mol . L(-1) induced contraction of strips in a concentration-dependent manne r. Dextromethorphan (Dex) 10 mu mol . L(-1), an antagonist of Phe rece ptor, antagonized the action of Phe. In vivo, Phe 10 mg . kg(-1) incre ased flow of left circumflex coronary artery of anesthetized dogs from 334 +/- 35 mL . kg(-1) . min(-1) to 510 +/- 58 mL . kg(-1). min(-1), and both left ventrical pressure (LVP) and blood pressure (BP) rose sl owly after medication. Dextromethorphan (Dex) 5 mg . kg(-1) also antag onized the effect of Phe. CONCLUSION: The regulation of Phe on coronar y artery in vivo differs from that in vitro, which may result in the c ontradictory effects.