DISSEMINATED BCG INFECTION IN SEVERE COMBINED IMMUNODEFICIENCY PRESENTING WITH SEVERE ANEMIA AND ASSOCIATED WITH GROSS HYPERSPLENISM AFTER BONE-MARROW TRANSPLANTATION

An infant with severe combined immunodeficiency (SCID) is described, w ho presented with severe anaemia and hepatosplenomegaly due to dissemi nated Bacillus Calmette-Guerin (BCG) infection involving the bone marr ow, liver and spleen, After BMT, huge splenic enlargement occurred, pr esumably due to proliferation of engrafted donor Lymphocytes, leading to severe hypersplenism. Peripheral blood cell consumption was resolve d by splenectomy, but gradual loss of the marrow graft followed.