NATIONAL TOXICOLOGY PROGRAM STUDIES - PRINCIPLES OF DOSE SELECTION AND APPLICATIONS TO MECHANISTIC BASED RISK ASSESSMENT

A workshop entitled ''NTP Studies: Principles of Dose Selection and Ap plications to Mechanistic Based Risk Assessment'' was held at the 34th Annual Meeting of the Society of Toxicology in Baltimore, Maryland. T he purpose of the workshop was to provide an overview of factors curre ntly considered important in the selection of doses for NTP studies, t o describe some of the confounding factors that can result from the in discriminate use of bioassay data in quantitative risk assessment; and to suggest ways in which information from mechanistic studies or stud ies of biomarkers of exposure or effect might be used to better advant age in risk assessment. (C) 1996 Society of Toxicology