Purpose of this study was to define a subgroup of TIA/stroke patients
who should be examined by transthoracal and transesophageal echocardio
graphy or Holter-electrocardiography to identify those with cardiogeni
c brain embolism reliably; 300 consecutive patients with acute focal b
rain ischemia underwent a standardized diagnostic protocol for the eva
luation of the etiology including, clinical examination by a cardiolog
ist and routine electrocardiography, Holter-electrocardiography, trans
thoracal and transesophageal echocardiography. 188 patients had a pote
ntial cardiac source of embolism. In particular echocardiography was d
iagnostic in 163 patients, and Holter-electrocardiography 10; 159 of t
hese 188 patients (84.6%) had competitive etiologies, predominantly la
rge vessel atherosclerosis. In 136 patients cardiogenic brain embolism
was assumed as quite definite or possible. To identify these patients
reliably, transthoracal and transesophageal echocardiography would ha
ve been necessary in 89% of the entire group of patients (all with cli
nically cardiological abnormalities, pathological routine EGG, without
vascular risk factors, or no atherosclerosis in duplex sonography), a
nd Holter-electrocardiography in 54%.