IDENTIFICATION OF A HELA MESSENGER-RNA FRACTION WHICH CORRECTS THE MITOMYCIN-C SENSITIVITY OF IRS1 CELLS

Authors
BENDER O JONES NJ SPERLING K DIGWEED M
Citation
O. Bender et al., IDENTIFICATION OF A HELA MESSENGER-RNA FRACTION WHICH CORRECTS THE MITOMYCIN-C SENSITIVITY OF IRS1 CELLS, Mutation research. DNA repair, 363(1), 1996, pp. 9-14
Citations number
27
Categorie Soggetti
Genetics & Heredity",Toxicology,"Biothechnology & Applied Migrobiology
Journal title
Mutation research. DNA repair → ACNP
ISSN journal
09218777
Volume
363
Issue
1
Year of publication
1996
Pages
9 - 14
Database
ISI
SICI code
0921-8777(1996)363:1<9:IOAHMF>2.0.ZU;2-U
Abstract
The hamster cell mutant irs1 is defective in its response to DNA lesio ns caused by a variety of mutagens, particularly cross-linking agents. These cells have been assigned to complementation group 2 of X-ray-se nsitive mutants and the mutated gene is called XRCC2 (X-ray repair cro ss complementing). We have identified, by microinjection, a human mRNA fraction which carl transiently correct the sensitivity of these cell s to cross-linking agents. This fraction contains mRNAs of 3.5 kb (+/- 0.25) including, therefore, the transcript of the XRCC2 gene.