Transphosphatidylation activity is a characteristic and remarkable pro
perty of phospholipase D (PLD) and has been studied in plants and mamm
alian tissues. This reaction is often used to confirm the properties a
nd/or abnormalities of PLD activity. The mechanism for activating PLD
transphosphatidylation seems multiple. Although significant changes of
transphosphatidylation activity have been found in some pathological
animal models, the biological significance of PLD transphosphatidylati
on remains largely unknown.