L. Posner et Mh. Mokrzycki, TRANSIENT CENTRAL DIABETES-INSIPIDUS IN THE SETTING OF UNDERLYING CHRONIC NEPHROGENIC DIABETES-INSIPIDUS ASSOCIATED WITH LITHIUM USE, American journal of nephrology, 16(4), 1996, pp. 339-343
Nephrogenic diabetes insipidus (NDI) is a well-documented complication
of lithium use. The association of central diabetes insipidus (CDI) w
ith lithium use is rare. We report a patient receiving chronic lithium
therapy who presented with a transient CDI occurring in the setting o
f underlying chronic NDI, To the best of our knowledge, this is the fi
rst case of lithium-associated CDI and NDI presenting concurrently. Po
tential mechanisms regarding the pathophysiology of lithium-associated
CDI are discussed, This case emphasizes the importance of the evaluat
ion of lithium-associated polyuria with a direct measurement of plasma
vasopressin, interpreted with simultaneous plasma and urine osmolalit
y to secure the correct diagnosis and ensure appropriate therapeutic m
anagement.