Major diagnostic difficulties are usually encountered when a food alle
rgy is suspected. After a long and precise clinical interview, clinica
l examination is often able to confirm the disease presented and asses
s the role of a possible allergic component. Skin tests, performed acc
ording to precise rules, confirm the sensitization and sometimes guide
the subsequent assessment and, in the absence of any ethical obstacle
, may indicate the need for a double-blind specific challenge test, th
e only way of confirming the responsibility of the food. In the absenc
e of this certainty, one or several specific food exclusions can be ju
diciously under close clinical surveillance. This exclusion should onl
y be continued when it induces lasting clinical remission.