UNJUSTLY EXCLUDED DRUGS - CHALLENGE TESTS

The development of abnormal manifestations during drug treatment usual ly leads to permanent exclusion of the suspected drug in children. 123 challenge tests concerning 18 drugs were performed in 87 children dur ing a day-only admission under maximal security conditions, in order t o confirm or invalidate the risk of allergic reaction. No immediate or delayed reactions were observed in 77 children during the 123 challen ges. The diagnosis of drug allergy was confirmed in 10 children: due t o amoxicillin 5 cases, ampicillin in 1 case, a cephalosporin in 1 case and aspirin in 3 cases.