Purpose: We determined whether the clinical and pathological features
of hereditary prostate cancer differ from those of sporadic prostate c
ancer. Materials and Methods: We compared the clinical and pathologica
l features of radical prostatectomy specimens from 50 men with and 50
without a family history of prostate cancer who were matched for age a
nd date of surgery. Results: Median serum prostate specific antigen co
ncentration was not significantly different in the 2 groups. Mean Glea
son score plus or minus standard deviation in the 50 men with sporadic
prostate cancer was 6.2 +/- 1 compared to 5.6 +/- 0.9 in those with h
ereditary disease (p = 0.008). Of the 50 hereditary and 50 sporadic pr
ostate cancers 35 (70%) and 33 (66%), respectively, were pathologicall
y organ confined (p = 0.69). Median percentage of carcinoma within the
gland (determined morphometrically) in men with hereditary disease wa
s 11.4 +/- 8.3 compared to 10.9 +/- 8.9 for those with sporadic cancer
(p = 0.63). Conclusions: In our study population hereditary prostate
cancers have significantly lower Gleason scores compared to sporadic c
arcinomas. Otherwise, there appear to be no substantial clinical or pa
thological differences.