A brief description of the effects that smallpox caused in the worldwi
de population places the events that gave rise to the evolution of the
concept and practice of the smallpox vaccine in context. Through a de
scription of various events in Jenner's life in relation to his study
and use of inoculation, the lessons that have been learned from the di
ssemination of the technique and the development of smallpox vaccinati
on campaigns and programs throughout the world are commented on. The a
rticle indicates that the analysis of the process that culminated in t
he eradication of smallpox has current applications in programs underw
ay to control, eliminate and eventually eradicate certain diseases. Fi
nally, some lessons are highlighted that have been used in successful
national, regional and worldwide vaccination campaigns in the struggle
against other infectious diseases.