MONOCLONAL GAMMOPATHY AND PRIMARY HYPERPA RATHYROIDISM - REPORT OF 2 CASES AND LITERATURE-REVIEW

Frequency of primary hyperparathyroidism (HP) is increased in neoplasi a. Though uncommon, both HP and monoclonal gammopathy are not exceptio nnally associated as seen in a literature review reporting 24 observat ions. The mechanism of this association remains unclear but does not s eems coincidental. Association of hypercalcemia with gammopathy does n ot suggest systematically malignant hypercalcemia and implies the sear ch for hyperparathyroidism. The authors report two patients presenting respectively a multiple IgD myeloma and an monoclonal gammopathy of u ndetermined signification associated with a parathyroid adenoma.