THE COPPER COMPLEX OF CAPTOPRIL IS NOT A SUPEROXIDE-DISMUTASE MIMIC -ARTIFACTS IN DMPO SPIN-TRAPPING

Authors
BARTOSZ M KEDZIORA J BARTOSZ G
Citation
M. Bartosz et al., THE COPPER COMPLEX OF CAPTOPRIL IS NOT A SUPEROXIDE-DISMUTASE MIMIC -ARTIFACTS IN DMPO SPIN-TRAPPING, Free radical research, 24(5), 1996, pp. 391-396
Citations number
14
Categorie Soggetti
Biology
Journal title
Free radical research → ACNP
ISSN journal
10715762
Volume
24
Issue
5
Year of publication
1996
Pages
391 - 396
Database
ISI
SICI code
1071-5762(1996)24:5<391:TCCOCI>2.0.ZU;2-T
Abstract
The effect of captopril and of its copper complex on several superoxid e-dependent reactions used to detect and assay superoxide dismutase ac tivity was studied, including pyrogallol and hematoxylin autoxidation and Nitro Blue Tetrazolium reduction. In none of these systems were su peroxide dismutase-like properties of captopril/Cu apparent. Captopril /Cu decreased the yield of DMPO-OH adducts generated by KO2 but this e ffect may be due to the acceleration of the decay of the adduct by cap topril/Cu.