GALLBLADDER EMPTYING AND CHOLECYSTOKININ RESPONSE TO FISH-OIL AND TRIOLEATE INGESTION

The aim of the present study was to compare gallbladder emptying, gast ric emptying and release of cholecystokinin (CCK), gastrin and secreti n after intragastric administration of fish oil and trioleate. After i ntravenous injection of Tc-99m-HIDA, 30 ml of a lipid labelled with In -111 was administered through a gastric tube. Using dual scintigraphy with two markers, gallbladder and gastric emptying were measured simul taneously for 120 min. Plasma concentrations of gastrin, secretin and CCK, were determined throughout the period. The emptying of the gallbl adder was reduced by 27% and the release of CCK by 85% after fish oil as compared with trioleate. Gastric emptying as well as the release of gastrin and secretin were similar after the two types of fat. The res ults suggest that the reduced gallbladder emptying after fish oil may be due to a smaller release of CCK.