Factors of predictive, prognostic value in endometrial neoplasia are c
lassic clinicopathological correlates, such as cytological and archite
ctural atypia and special variants of adenocarcinoma, as well as the e
xtent of invasion and spread. Advances in molecular biology in the fie
ld of oncogenes, cell proliferation studies, and so on have, as yet, f
ailed to provide an alternative to traditional prognostic parameters.
The overvaluation of these data may lead to overtreatment.