Over the past 25 years, investigators have continued to improve on the
approach to providing non-irritant exposures for the accurate diagnos
is of isocyanate-induced asthma, Although the technology used in testi
ng has become more sophisticated and may be fail ly considered the dom
ain of the bioengineer, the chemist, and the industrial hygienist, the
requirements of the physician have remained unchanged. The physician
must observe the level of exposure closely and monitor the worker's sy
mptoms and lung function. Direct physician involvement in the testing
procedure remains critical to the worker's safety and for the accurate
diagnosis of isocyanate-induced asthma.