H. Kawaguchi et al., MODIFICATION AND FUNCTIONALIZATION OF HYDROGEL MICROSPHERES, Colloids and surfaces. A, Physicochemical and engineering aspects, 109, 1996, pp. 147-154
Acrylamide (AAm)-methacrylic acid (MAc)-methylenebisacrylamide (MBAAm)
terpolymer microspheres and AAm-MAc-MBAAm-nitrophenyl acrylate (NPA)
quaterpolymer microspheres with high monodispersity were prepared by p
recipitation polymerization in alcohol. The former were modified into
composite microspheres containing hydrophobic domains or magnetite nan
ospheres. The active ester in the quaterpolymer microspheres was allow
ed to undergo hydrolysis or aminolysis to prepare novel microspheres s
uch as highly negative, amphoteric, hydrophobic or bioconjugate micros
pheres.