ANTIBACTERIAL EFFECT OF SUBSTITUTED 4-QUINAZOLYLHYDRAZINES AND THEIR ARYLHYDRAZONES DETERMINED BY A MODIFIED MICRODILUTION METHOD

Eight 4-quinazolylhydrazines and eleven their arylhydrazones have been tested for antibacterial effects and for structure - activity relatio nships by a modified microdilution method. The derivative -morpholino- 4-quinazoly-5'-nitro-2'-furylhydrazone had the highest antibacterial e ffect, the MIC values being 100 mg/L for E. faecalis, 250 mg/L for S. aureus, 200 mg/L for P. aeruginosa and 350 mg/L for E. coli. The most effective derivatives were those with the benzene ring substituted wit h chlorine or methyl group in position 6 or 8 and with pyrimidine ring substituted with a secondary amine in position 2. The modified microd ilution method did not give rise to any statistically significant devi ations in the MIC values for ampicillin in comparison with reported re ference collection values.