Effects of ethanol (0.55 and 0.85 g/kg) on event-related potentials we
re investigated by presenting 50-ms standard and 25-ms deviant pure to
nes to 9 social drinkers during a reading task, in a single-blind, pla
cebo-controlled paradigm. Whereas the lower ethanol dose had no impact
on ERPs with an 0.8-s inter-stimulus interval (ISI), it attenuated th
e N1, P2, and mismatch negativity (MMN) amplitudes with a longer ISI o
f 2.4 s. The higher alcohol dose increased the N1 peak latency with bo
th ISIs. It also suppressed the N1 and MMN amplitudes with the longer
ISI, The MMN suppression did not, however, occur at scalp sites below
the Sylvian fissure, thus suggesting that ethanol affected only the fr
ontal MMN subgenerator. Moreover, the different dose responses of the
N1, P2, and MMN (subcomponents) to ethanol may indicate that the neuro
transmitter systems underlying their generation are, to some extent, d
ifferent.