TRANSGENIC MOUSE MODELS OF BREAST-CANCER

Although valuable initial information can be gathered about transforma tion from in vitro studies, human cancer occurs in the context of a co mplex interaction with its environment and must ultimately be studied in living animals. Transgenic animal models have been used to study br east transformation for a number of years and have yielded valuable in formation on the subject. In this paper, we will summarize results fro m our laboratories, and others, regarding the use of transgenic mice t o study breast tumorigenesis. We will also suggest future directions f or the use of transgenic models to understand, and hopefully, one day to cure the disease.