IS BLOOD-PRESSURE THE MAJOR DETERMINANT OF LEFT-VENTRICULAR MASS IN SUBJECTS OVER 50 YEARS OF AGE

The weak relation of systolic blood pressure to left ventricular (LV) mass in hypertension has frequently been regarded as evidence of non-h emodynamic stimuli to muscle growth. Anyway, left ventricular hypertro phy (LVH) is associated with a significantly increased risk for cardio vascular events. Data were obtained from M-mode echocardiograms in 10 normotensives and 58 hypertensives over 50 years (range 50-85 years); 18 hypertensives; were without (LVH -) and 40 were with LVH (LVH +) - when LV mass, normalized for body surface area, was calculated accordi ng to the Penn's Convention. Cardiac output was derived by Teicholz fo rmula for LV volumes. End-systolic stress/end-systolic dimension ratio (ESS/ESD r), an index of myocardial contractility, was calculated as previously validated in the literature. We found that, in subjects ran ging from 50 to 85 years of age, the presence of LV hypertrophy is not necessarily associated with raised blood pressure levels. Systolic fu nction was substantially preserved among the study groups, irrespectiv e of their age, hypertensive condition and/or presence of LVH. The inc reased wall thickness in subjects with LVH was associated with a signi ficant reduction in wall stress (thus suggesting an adequateness of th e compensatory role of LVH - at least at the observed stage of the hyp ertrophic process) and with a significant decrease of the contractile performance. On the multivariate analysis, the observed relation of LV mass to blood pressure and myocardial contractility (r = 0.621, P < 0 .001) may explain some apparently conflicting findings, such as the la ck of LV hypertrophy in a number of hypertensive patients.